“Cancer and Alzheimer’s metabolism, prevention, calorie restriction, metabolic therapies with Dr. George Yu”
Interviewed: Monday, September 25, 2017
Location: Dr. Yu’s office in Annapolis, MD
Show Notes & Publishing: Friday, October 13, 2017
Cancer and Alzheimer’s metabolism, prevention, calorie restriction, metabolic therapies with Dr. George Yu
For the Conference from November 3rd through 5th in Baltimore, please find the details and registration at https://www.trippingoverthetruth.org
[For Dr. Yu’s background and credentials and publishing history, please see the end of these show notes. They are extensive!]
Introduction (0 – 4:00): A few weeks ago, I had the great pleasure of sitting down with Dr. George Yu. Quick to tell me he was 70 years old, I was floored. I had him pegged in his 50’s. Still in his doctor’s gear and wearing the clogs of an old-time surgeon, he has the energy of a 25-year-old. Maybe even the energy level of a well-rested and welI-fed child. Seriously. So read on or keep listening.
I first heard Dr. Yu speak at a Macrobiotic conference five years ago. It was a big hall. I was sitting in the back, as usual, wanting the option to duck out if the speaker proved boring, but this physically small man with a booming voice and huge presence stood up and started speaking. To paraphrase, he said: “I don’t mean anyone any disrespect, but I have studied the data on The Kushi Institute & Macrobiotics, Omega Institute and The Hippocrates Institute, and with cancer patients I consistently find that you have similar results, and my analysis points to calorie restriction. You are all providing high nutrient, low calorie diets. I have found that roughly one-third (1/3) of each of your patients respond very well to low calorie diets.” I knew I loved this man! Not afraid to speak his mind!
Having lived in Philadelphia and gone to The University of Pennsylvania, I knew of the department store Wanamaker’s. John Wanamaker was famous for the quote: “Half the money I spend on advertising is wasted; the trouble is, I don’t know which half.” So, we know that the data suggests that 1/3 of cancer patients will recover simply by eating healthier, lower calorie diets until things clear up, but for now at least, we don’t know which third. I would also add that other factors including stress, exercise and physical and personal environment matters. Dr. Yu’s Totally Yu program is, in fact, about “Y-O-U.”
Dr. Yu is a surgeon trained in the pelvic area with a specialty in urology. Many years ago, his mindset transformed when he became a patient. Though he continued as a practicing surgeon for many years, he started treating the whole body; today, he no longer operates, though still refers people to surgery when needed. For those in the more traditional structured Western Medicine world, I think his experience and success bears listening. Personally, I have had more than one relative who got completely different opinions between the Mayo Clinic and Sloan Kettering. So, trust me, even among the best, there are differences in mindset and thus opinion!
The wall in his office is littered with pictures of famous people with more wording and deeper meaning than mere signatures and a “thanks.” The pictures are also not displayed to beat his chest. Rather, it feels like he is grateful that they have entrusted their lives to him.
Regardless of what you have: cancer, autoimmune, hormonal imbalances, which can lead to certain cancers, whatever… you should listen to Dr. Yu. He is thoughtful, scientific, methodical, curious and creative. And he believes in using standard of care in conjunction with metabolic therapies including a low calorie and / or ketogenic diet among other drugs that mimic that effect. He also is a believer that when you use these adjunctive therapies that you can make due with lower doses of chemotherapy, and hopefully with success, less radiation and other toxic treatments. His goal is to give you the most effective treatment that leaves you with the least long-term systemic bodily damage.
On November, 3rd, 4th and 5th, with Travis Christofferson, he is co-hosting the Tripping Over The Truth Conference in Baltimore. Researchers and doctors from all over the world are flying in for this Friday through Sunday Conference to hear thought leaders show results of their work and share best practices. I will certainly be there and suggest you consider it. I have linked to the conference page above and will have it on our web site. The title is based on a book written by Travis Christofferson, a relatively new but already good friend. That book tracks the practical elimination of metabolic therapies from the standard of care for cancer treatment. I go back to what I wish could be the name of this podcast series, which is: “Give me every edge I can get.” Dr. Yu does just that.
And with that, here is Dr. George Yu…
Background and Evolution in Thinking – (0:00 to 5:00): Dr. Yu’s view on cancer and all diseases has evolved over many years. He retains incredible curiosity and humility in what he does.
Curiosity is more important than anything else. Einstein said, Imagination is more important than intelligence. He was born in China, and lived all over Asia, Europe and Latin America. Gave him the first clue that life was different everywhere and that everyone knew things that others did not know.
Dr. Yu went to Tufts Medical School and did his residency at The Brigham in general surgery and then down to Johns Hopkins for his subspecialty. He did tours of missionary surgery.
Dr. Irvine and Dennis Burkett. Never felt that food could be that important as fiber. Never saw colon cancer, diverticulosis nor ulcerative colitis in those patients on which they operated. So he had a broad exposure to different practices.
He was set on being a surgeon of the pelvic area of men and women and even did sex change operations. After 35 years of being a surgeon, he felt he picked up other tools / knowledge along the way. For the men who went through a sex change, by example, many of them developed diabetes. So, there was a relationship.
First change in thinking was in 1999. He noticed that post pelvic surgery for women, they got hormones (supplement) and they told him they slept better and thought better. For men with prostate cancer who were castrated, they became metabolic syndromes. Bones thinned and they became diabetics.
90% of cancers show glucose sensitivity up front. Prostate cancer does not at first, but the metastases do show that. 2 deoxyglucose positive in their PET scans. Saw there was a metabolic involvement and saw this as the evolution of his practice and could he use these insights to help people BEFORE they got to the operating table.
Current Work – Cancers and Chronic Diseases – (5:00 – 6:50): Currently still affiliated with GW, and Tom Jarrett, the chairman who Dr. Yu helped recruit from Johns Hopkins and Cornell. Dr. Yu became more interested in the hormonal and metabolic effects of cancers and chronic diseases. Chairman of Urology and Dr. Yu are currently working on research on mitochondria metabolism. Post castration, men immediately get tired.
Sees a clear correlation between the science and reality.
Private Practice – Sex Hormones and Nutrition 6:50 – 9:45 – His private practice is about giving his patients the latest information versus waiting for the practice of medicine to take its usual 15 years to change.
His biggest current focus is in sex hormones well beyond the basics. Sees serious estrogen, estradiol imbalances and with dense breast tissue they also see this imbalance. It helps with weight, mental state and the problems disappear. He sees this repeatedly. Note: he showed me a redacted (name) copy of a woman’s dense breast tissue and then a follow up picture where it was back to normal. He has it well documented in many cases.
Insulin Hemoglobin A1C and now Beta Hydroxy Butyrate lab tests, which shows the shift between carobyhydrate metabolism and oil. So, they balance everything. Hypothyroidism is most common in women and related to hormones. When you balance it, it decreases. Common is 20% decrease in thyroid function due to menopause.
When I first heard Dr. Yu Speak – Dr. Yu’s Protocol: 9:45 – 26:20
As clinicians, not pure scientists, they do not treat lab rats, and they talk back. Patients have desires, problems and things they can and cannot do. He found that when weight down 10%, their insulin went down to 4 or 5 and their A1C dropped from 7 to 5, they saw that their cancers went away. In the Best Case Series, their visceral fat and subcutaneous fat went away when the tumors regressed. In all of the fancy diets. All beautifully demonstrated by Roy Wolford who believed in calorie restriction. McKay at Cornell and his professor at Penn, Dr. Krocheski (sp?), caused cancer to regress. Biosphere 2 was most expensive test and in all, blood pressure went down, all problems went away – to a beautiful state – temporarily. But long term there would be endocrine problems and osteoporosis. After staging parameters…. He is a surgeon and believes in surgery, chemotherapy and radiation but add nutrition. If PET scan positive, start with calorie restricted diet and let’s see. If prostate and breast cancer, then look at baseline hormone studies. Likes metformin as a tool. PSA drops when you go into a low carbohydrate diet and metformin is antidiabetic drug and may be a repurposed drug for cancer. Pamela Goodwin at University of Toronto is following a large group for breast cancer – using metformin and seeing that the cancer spread slows. Would consider mebendazole, an anti-worm drug and Lipitor and NSAIDs. Use calorie restriction and enhance ketosis part. Primitive cancer cells initially act like yeast and thus can’t even have carrots nor bananas, despite nutritional benefits. It pushes up the blood sugar. They use oils like coconut oil, capryllic oil, MCT oil with no accumulation of fat. Then boost respiration, pushing glycolysis to the Background using oxygen, thus the Kreb’s cycle. So, hyperbaric oxygen therapy or liquid oxygen. Substrates like Oxaloacetate. Had dogs take that and cancers went away. So, going away from pure glycolysis, which is fermentation over to better respiration. Cancer cells gradually transfer what they can eat. So multi sequential approach. Then use metabolic blocking agents. He has not seen anyone completely cured by nutritional approaches in the long run. 1/3 do very well on calorie restriction. Malignant melanoma and pancreatic cancer. 2/3 do better in beginning but a year or two later they regress. Points to Tom Seyfried’s work (he will be in our series in the next few weeks!), that the mitochondria may be the first dysfunctional part of carcinomatosis and may cause insults either nuclear or in the membrane that causes a shift in the way that the cells feed themselves. Want things like 2 deoxyglucose, dichloroacid protocols and the big poster child: 3 Bromopyruvate from Dr. Peterson and Dr. Yan… at Johns Hopkins. 3BP tricks the body into letting it go inside the cancer cell and not the normal cell and thus causes damage only to the cancer cells as they are acidic. Like a Trojan Horse. At NCI screening, in 60 in vitro cases, most cancers all were impressively dying out very quickly. Whether the pharmacokinetics are good, we don’t yet know. Dichloroacetate is used all over the world. Now. Also, cancers use glutamine. Use phenylbutyrate to block that. And Dr. Seyfried uses DON, an anti-worm drug that may have a metabolic effect. Care Oncology, in London, uses mebendazole for glioblastoma (we will soon interview Greg Stoloff and Travis Christofferson) and Dr. Greg Riggins at Johns Hopkins who said it has effects on other cancers. So we will see a whole array of metabolic blocking agents as well as repurposed drugs. Thus, he believes we will soon broadly use chemotherapy traditionally along with these drugs and nutrition to handle the cancer. When a person has metastatic disease and they want to test if the cancer is sensitive to the chemotherapy, they try “metabolically enhanced chemotherapy” – insulin potentiation and lower blood sugar and then give the chemo or immunotherapy and it may have a much bigger effect. Has seen doctors use 30% of chemotherapy and using that regimen cancers disappeared in several cases he has seen. In England and in Turkey, where they have fairly large series of doing this with great results. When a person does get chemotherapy, main affects last 7 hours. But side affects come days later. They encourage those patients to take homeopathic dilutions of herbs and others to decrease side effects. Very common in France. Two simple homeopathic doses and long / well practiced in France. Saunas pull out chemotherapy. They can smell the chemo. Same with anesthesia and other drugs. So, they always personalize and check pathology with their own pathologists. Look at type and grade and look at radiology with their radiology and may test blood to see if cancer is growing even if radiologic results show negative.
Follow Up – 26:20 – 29:10: Usually, sent as a second opinion. First, go through every study and make an overall recommendation and then repeat the PET scan in two months to see status. Then six months later, they would send a blood test to Switzerland and other labs to see if there are cancer cells in the blood versus radiological studies. Then they would get suggestions from the labs that target your cancer. Then send people to institutions to start metabolic therapies. Also use up to 20mg of melatonin. Literature shows a lot of work on it. Know that melatonin and prolactin enhance body’s ability to clean up your body when sleeping. First three hours is melatonin production and second is prolactin to clean up the dirty stuff in your body daily. Six hours is so important!
Prevention – 29:10 – 33:00: Recommendations: if you can’t eat, the body says shut it down. If you eat everything, that’s not good. Age matters. Fasting in religious groups has always worked. It’s a clean-up job. Calorie restriction is just an extension of fasting. People don’t eat as much as they used to so they don’t need it. But an active farmer may need a lot more calories. Cycling of fasting and eating abundantly. Too much made about one diet. Body doesn’t like that – needs a happy medium. And if you’re on calorie restriction too long, it leads to problems. Intermittently fasting and eating abundantly is more effective. Future looks good for 3BP, even at homeopathic doses. Can stop bad cells from proliferating. Breathing is critical! Proper respiration, oxygen, proper sleep are all critical in health. As you age, your hormones change. Can make the process much better – to pass through menopausal and andropausal stage smoothly instead of erratically and make life better and avoid breast cancer and uterine fibroids – before you get the inklings of a solid mass.
Electromagnetic Frequencies (EMF’s) – 33:00 – 34:00) – Electrical Toxicity. Book: Dirty Electricity by Sam Milham. You have to get those frequencies out of your body. Using a sauna and niacin, you can get sunlight out of your body 10 years ago. He brought it to the Hiroshima Institute of Biology. Niacin and a hot hot bath or sauna and get it out. He sees radiation as a toxic chemical that you can’t see. Have to consider to be well.
GI Tract through Mitochondria – 34:00 – 36:00. People on sauerkraut and miso had great looking colons. Swedish bitters. Or get fenebranca, but also believe in good fiber. Psyllium husk to clean yourself out and acts as a prebiotic. Also uses charcoal tablets to absorb. Periodically, when kids eat bad food, they take 5 charcoal tablets and problems go away. Uses it overseas. Coca Cola can even be helpful. Not everything is bad. Just the way you use it and tailor it to your own body.
Conference (36:00 – 41:20): It is a retreat, not just a conference. 40 speakers. Putting the science with the food. Dr. Veech discovered Beta Hydroxy Butyrate and he will present. So, mix the scientists, chefs and nutritionists, but got the Maritime Conference Center in Baltimore and can hold 900 people. NOVEMBER 3RD THROUGH 5TH. Will have breakout sessions and will videotape it. Working with his foundation and Travis Christofferson and the Reichart Foundation. The conference is on BOTH cancer and Alzheimer’s. Focus is metabolic therapies. Alzheimer’s is like a Diabetes Type 3. In brain cancer, they have too much sugar, but when you use Beta Hydroxybutyrate, you can kill cancer while you feed the brain for Alzheimer’s. Thus you mix the two. There will be a lot of science. Much of it from John’s Hopkins including Albert Lenninger and Pete Pederson’s work from 1978 – where they spoke about cancer mitochondria being very abnormal. https://www.trippingoverthetruth.org
One Last Question – What drives you?! (41:20 – 49:00): Necessity is the mother of invention. When he was at Harvard well over 40 years ago, he had an ulcer and they wanted to operate. But a friend from Australia convinced him to take antibiotics and a few other more benign drugs and in less than six months he was fine. He did surgery in Japan and realized how good they were at liver disease. Burkett’s Lymphoma – Dr. Burkett convinced him to use less chemotherapy. In other countries, they couldn’t use C-sections, so they did another procedure and the women were all fine. You learn there are many ways to do things. Dr. Yu is a traditional surgeon but realizes you have to go beyond it and look at nutrition, and metabolism is nutrition. For his colleagues who are less willing to objectively look at this and research it, they may have pressures that don’t allow them to do this. Each one of us has something to offer and he tries to offer what needs to be done and might be slightly ahead of the curve before it is standard of therapy. Ex: Metformin is becoming important and even topically (on the skin). In the old days, it was radical mastectomies and now it is lumpectomies with greater frequency. So, his mission is to find and get the word out about newer approaches…. It’s a people problem. Must look at what’s not doing well. Sidney Farber, one of his greatest heroes, The Godfather of oncology and chemotherapy, was not happy with the way things were done. He pushed to new frontiers. So, Dr. Yu feels compelled to keep pushing forward for better and better therapies. Tom Seyfried is leading the way and traveling all over the world. He is talking. You need a soldier, momentum and people who are willing to listen. “Necessity is the mother of invention because something is not working so we need to approach it that way.”
People and Drugs Mentioned in this Podcast
- Tom Jarrett
- Roy Walford
- McKay (sp?) at Cornell
- Krocheski (sp?)
- Biosphere 2
- Pamela Goodwin at University of Toronto – easiest to Google her name
- Mebendazole – Google “Mebendazole Cancer”
- Metformin – Google “Metformin Cancer”
- 3 Bromopyruvate – best to Google
- 2 Deoxyglucose
- Pete Pederson at Johns Hopkins
- Tom Seyfried
- Dichloroacetate
- Book: Dirty Electricity by Sam Milham
Doctor Yu’s Curriculum Vitae
Faculty Appointment:
- George Washington University Medical Center, Department of Urology
- Clinical Professor of Urology – 1981 to present
Educational and Medical Training:
- Tufts University School of Medicine Boston, Mass., Doctorate of Medicine – 1973
- Peter Bent Brigham Hospital-Harvard Medical School Boston, Mass. , Surgical residency – 1976
- Johns Hopkins University Medical Center, Baltimore, Md., Residency in Urology – 1981
Professional Status:
- Use of Medium Chain Fatty Acids as a secondary source of energy in disease states
- Short Term and Long Term Caloric Restriction in Aging and Disease
- Focus on aging male and female sex hormone changes, age decline in digestibility, anabolic and catabolic changes with aging, libido and erectile dysfunctions in aging male and females 2008
- Active practice in Urological surgery – 1981 to 12/31/2007
- Medical Missionary work Cameroon (1973), Malawi (1976), Honduras (1998)
- Clinical Professor of Urology, Dept. of Urology, George Washington University Medical Center – 1981 to present 2012
- Reviewer for the journal Urology – 1995 to present
- Reviewer for Aging Male journal- 2009
- Reviewer for Sexual Medicine Journal – 2008 to present
- Author of textbooks on operative and medical urology – last, Critical Operative
- Maneuvers in Urologic Surgery, 1996 Mosby/Harcourt publisher
- Research in medical and surgical treatments in Urology
- Research and Development in surgical instrumentation and catheter design
- Dean’s committee for the search for the new Chairperson in Urology, G.W.U.M.C. 2004, 2006
Professional Societies:
- 1992-2000 International College of Surgeons
- 1992-1994 American Urological Association – International Relations Committee
- 1986-2009 American Urological Association, Past Active Member
- Inventions and Technical Consultation on New Products:
- 1998 Design for new Foley catheter for males; design for new Catheter (for females) for space travel
- 1998 Retractor system for perineal prostatectomy
- 1995 Patent #5,487,746 for the Internal Open and Laparoscopic Y-Clip. The unique design, using same materials as Available clips, is 6X stronger in holding strength than other clips as shown by an independent investigation done at the Whiting School of Materials and Engineering at The Johns Hopkins University in Baltimore, Maryland
- 1992 Yu-Holtgrewe Prostate Retraction Blade for the Radical Retropubic Prostatectomy. Manufactured by Greishaber, Inc. 7020 West Cullom Avenue Norridge, IL 60634, and distributed by J. Hugh Knight Instrument Company, 226 South Villere Street, New Orleans, LA 70112
- 2005 Cryosurgery probe for prostate and grid design
- 2006 Design of ureteral stent with no bladder spasm
Bibliography:
- Yu GW, Mylander C, Triash AM, Hormone Mol Biol Clin Invest Special Issue of Hormones in Normal and Pathological Prostate Cancer Circulating Levels of Gonadotropins Before and After Prostate Ablation in Cancer Patients is accepted for publication 2012
- Triash AM, Yu GW, J Hormone Mol Biol Clin Invest 2011; 8 (1): 425-430 Androgen Deficiency and Mitochondrial Dysfunction: Implications of Fatigue, Muscle Dysfunction, Insulin Resistance, Diabetes and Cardiovascular Disease
- Yu, GW, Triash AM, J Hormone Mol Biol Clin Invest 2011;8(1): 425-430 Induced Testosterone Deficiency: From Clinical Presentation of Fatigue, Erectile Dysfunction and Muscle Atrophy to Insulin Resistance and Diabetes (As a Spectrum of Mitochondrial Dysfunction)
- Yu GW, laseter J, Mylander C, Journal of Environmental and Public Health 2011, Volume 2011( 2011) Article ID 417980 9 (8 pages) Persistent Organic Pollutants in Serum and Several Different Fat Compartments in Humans
- Yu, GW; Miller, HC: Critical Operative Maneuvers in Urologic Surgery, Mosby Yearbook Division of Times-Mirror Publishing, March 1996. First surgical textbook to use: interactive CD ROM, 3-Dimensional illustrations with 360-degree rotation of surgical anatomy as supplement; displayed in William Didush Urological Museum, Baltimore, Maryland
- Chung, s; Yu, GW; Miller, HC: “Stapling Bladder Pedicles in Radical Cystectomy” Cont. Urol. Jan. 1996.
- Yu, GW; Chung, S: Video Instructions on Use of GIA Stapling Techniques of (1) the Bladder Pedicles In Radical Cystectomy and (2) Indiana Pouch – Urinary Continent Diversion
- Yu, GW; Melograna, FS; Miller, HC: Surgical Modifications for the Ligation of the Deep Dorsal Vein Complex from the Retropubic Space: Urol. 40:6, Dec. 1992.
- Holtgrewe, HL: Yu, GW; Jacobs, GN: “A Modified Surgical Retractor Blade for Radical Retropubic Prostatectomy and Retropubic Surgery” J. Urol. 148:353, Aug. 1992.
- Yu, GW; Schwab, FJ; Melograna, FS; Miller, HC; Rickholt, A: Preoperative and Postoperative Dynamic Cavernosography and Cavrnosometry: Objective Assessment of Venous Ligation For Impotence J. Urol. 147:618-622, Mar. 1992
- Paper Presentations, Conference Presentations, Television and Radio Talk Shows, Conference
Moderations:
- 04/2010 Eastman Resort Montreal Canada, Female Sex Hormone and Health
- 10/2009 ZRT conference on Hormones and cancer presentation of Testosterone and Prostate Cancer
- 07/2009 Summer Conference for the Macrobiotic Association at the IBM executive center , New York On Caloric Restriction Is the Common Denominator in Nutritional Intervention for Terminal Cancer Disease
- 10/2008 American Osteopathic Association Meeting Presentation on Anabolic Dominance and Tissue Integrity and Repair, Las Vegas, Nevada
- 10/2008 Diane Brandon Radio show in Tenn. on Toxic Chemicals in Fat
- 05/2008 Donna Laake Radio show in Maryland on Toxic Chemicals and detoxification methods.
- 02/2008 Conference on Aging Males Meeting on LH and FSH elevation after cryosurgery for prostate Cancer.
- 05/2008 George Washington Medical Center, Center for Integrative Medicine, Toxic Chemicals in Fatty Tissues
- 07/2006 Kushi Macrobiotics Presentation on Fat Toxins and the Need to Detoxify
- 06/2006 American Environmental Health Presentation of Part 2, Further Analysis of Toxins in Fat of the Visceral Compartment
- 09/2005 FASC Presentation of Toxic Chemical Load in Fat Compartments of the Body
- 02/2002 NIH CAM Presentation of the Best Case Series of Terminal Cancer and Nutritional Intervention
- 1997 Tribute to Janet Travell, M.D. Special Edition, 1997 National Association of Myofascial Trigger Point Therapists
- 03/1996 Conference on Acupuncture and Trigger Points with Janet Travell, M.D. Annapolis, Maryland Chairman and Moderator
- 01/1996 Medical Technology and Inventors Conference: Lateral Thinking – Edward de Bono A Tribute to Dr. Phillip Henry Meyers, founder of E-Z-EM Corporation New Orleans, Louisiana Chairman and Moderator
- 10/1992 Paper presentation in Washington, DC, Mid-Atlantic American Urological Association: Manyak, MJ; Ahlgren, JD; McNellis, RJ; Lynne, J; Yu, GW; Myers, CE: Cumulative Dose-Related Suramin Toxicity in Patients with Hormone Refractive Metastatic Prostate Carcinoma.
- 09/1990 Paper presentation in Rio de Janeiro, S.A., at the IV World Meeting on Impotence, VII Symposium on Corpus Cavernosum Revascularization: Yu, GW; Schwab, FJ; Melograna, FS; Miller, HC; Rickholt, AL: “Preoperative and Postoperative Dynamic Cavernosography and Cavrnosometry: Objective Assessment of Venous Ligation For Impotence.”
- 09/1990 Paper presentation in Rio de Janeiro, S.A., at the IV World Meeting on Impotence, VII Symposium on Corpus Cavernosum Revascularization: Yu, GW; Melograna, FS; DePalma, RG; and Miller, HC: “A Surgical Retropubic Approach for the Treatment of Impotence Secondary to Venous Leakage.”
- 09/1989 Paper presentation in Munich, Germany, at the Mid-Atlantic American Urological Association in conjunction with the International Urological Association: Yu, GW; Schwab, FJ; Melograna, FS; Miller, HC; Rickholt, AL: “Preoperative and Postoperative Dynamic Cavernosography and Cavrnosometry in Impotent Patients with Venous Leakage Incompetence.”